|
Symbol Name ID |
Gck
glucokinase MGI:1270854 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Diabetes mellitus |
Maturity-onset diabetes of the young |
Type I diabetes mellitus |
Type II diabetes mellitus |
Fasting hyperinsulinemia |
Hyperinsulinemic hypoglycemia |
| Disease(s) Associated with GCK | ||||||
| coronary artery disease | ||||||
| familial hyperinsulinemic hypoglycemia 3 | ||||||
| maturity-onset diabetes of the young type 2 | ||||||
| permanent neonatal diabetes mellitus | ||||||
| type 2 diabetes mellitus |
| Mouse Phenotypes | increased pancreatic beta cell proliferation |
endocrine/exocrine gland phenotype |
abnormal pancreatic islet morphology |
abnormal pancreatic beta cell morphology |
decreased pancreatic beta cell mass |
increased pancreatic beta cell mass |
small pancreatic islets |
abnormal endocrine pancreas physiology |
abnormal pancreatic beta cell physiology |
abnormal insulin secretion |
decreased insulin secretion |
increased insulin secretion |
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| Availability | Mouse Genotype | ||||||||||||
| GckGls006/GckGls006 | |||||||||||||
| Gcktm1Tka/Gcktm1Tka | * | ||||||||||||
| Gcktm3Mgn/Gcktm3Mgn | |||||||||||||
| GckGls006/Gck+ | |||||||||||||
| Gckm1Rge/Gck+ | |||||||||||||
| Gcktm1.2Mgn/Gck+ | |||||||||||||
| Gcktm1Tka/Gck+ | |||||||||||||
| Gcktm2Mgn/Gck+ | * | ||||||||||||
| Gcktm3Mgn/Gck+ | * | ||||||||||||
| Gcktm1.1Mgn/Gcktm1.1Mgn Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Gcktm1.1Mgn/Gck+ Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Gcktm1Hrt/Gck+ Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Gcktm1Ydor/Gck+ Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Gcktm1Ydor/Gck+ Tg(Ins1-cre/ERT)1Lphi/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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